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A welcome message from the Chair of the Consortium

 The focus and the work product of this Consortium is dedicated to all members of the Armed Forces, especially our Wounded Warriors.



The Major Extremity Trauma Research Consortium is funded through cooperative agreements with the United States Army Institute of Surgical Research (USAISR) Orthopaedic Extremity Trauma Research Program (OETRP) (Award # W81XWH-09-2-0108) and the DOD Peer Reviewed Orthopaedic Research Program (PRORP) of the Congressionally Directed Medical Research Program (CDMRP) (Award # W81XWH-10-2-0090).

Vanco Study

Vanco Study


Local Antibiotic Therapy to Reduce Infection after Operative Treatment of Fractures

at High Risk of Infection: A Multicenter Randomized, Controlled Trial


Principal Investigator: Robert V. O’Toole, MD


The primary objective of this study is to compare the proportion of deep surgical site infections within 6 months in patients treated with local Vancomycin powders compared to those treated without local Vancomycin powder. Secondary objectives include: 1) to compare antibiotic sensitivities of the bacteria in the patients who develop surgical site infections in study patients treated with local Vancomycin powder compared to those treated without local Vancomycin powder; and 2) to build and validate a risk prediction model for the development of surgical site infections in patients treated without local Vancomycin powders. Further, to explore whether the effect of local Vancomycin powder is modified by the predicted risk of infection.


This study is being funded by DOD CDMRP (award number W81XWH-10-2-0134).