PACS Study

PACS Study


Predicting Acute Compartment Syndrome using Optimized Clinical Assessment, Continuous Pressure Monitoring, and Continuous Tissue Oximetry



Co-Principal Investigators: Dr. Andrew Schmidt and Dr. Michael Shuler

The long-term objective of thisresearch is to develop a tool that can aid clinicians in making a timely and accurate diagnosis of acute compartment syndrome (ACS) so that early fasciotomy can be done and unnecessary fasciotomy avoided. The immediate objective is to develop a model that accurately predicts the likelihood of ACS based on data available to the clinician within the first 48-72 hours of injury. Such data will include specific clinical findings, physiologic monitoring using muscle oxygenation measured with near-infrared spectroscopy (NIRS), continuous monitoring of intramuscular pressure (IMP) and perfusion pressure (PP), and serum markers of muscle injury (CPK levels).


This study is being funded by DOD CDMRP PRORP (W81XWH-10-2-0090).