Streamlining Trauma Research Evaluation with Advanced Measurement


Principal Investigator: Renan Castillo, PhD


This study will examine the reliability, validity and responsiveness of the PROMIS tools for clinical research following orthopaedic trauma.
As part of the NIH Roadmap initiative, PROMIS (patient reported outcomes measurement information system) has developed tools, including item banks, short forms and computer-adaptive tests (CATs) that can help standardize measurement for many health-related quality of life domains. These PROMIS tools are being tested in large general population samples across the lifespan. The overall goal of this study is to assess the performance and research utility of these new tools in new patient populations for future comparative effectiveness research projects.
The STREAM study is a multi-center, prospective longitudinal observational study to evaluate the reliability, validity and responsiveness of PROMIS tools in orthopaedic trauma patients. This study is an ancillary project to four METRC clinical trials and is designed to study the validity, reliability and responsiveness of the PROMIS tools for assessing: Ability to participate in social roles and activities, Depression; Anxiety; Psychosocial Impact (Positive); Pain Interference; and Physical Function.  The study will also explore three additional PROMIS domains (Sleep; Satisfaction with participation in social roles; Applied Cognition; and Emotional Support).

This study is being funded by the National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases Award (1R01AR064066-01).