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Daniel O. Scharfstein, ScD

Professor of Biostatistics


Daniel O. Scharfstein, PhD is Professor of Biostatistics at the Johns Hopkins Bloomberg School of Public Health. He received his doctoral degree in Biostatistics from the Harvard School of Public Health, where he also completed an 18 month post-doctoral fellowship. He joined the faculty at Johns Hopkins as an assistant professor in 1997 and was promoted to full professor with tenure in 2008. Since 2003, he has been the director of graduate studies in Biostatistics. Dr. Scharfstein's research is focused on the development of statistical methods for the analysis of studies in which there are concerns about potential biases due to factors such as non-random treatment assignment and missing data. In these settings, he has strongly advocated for better design as well as the use of sensitivity analysis and Bayesian methods as a way of reporting study results. He has consulted with the FDA on the issue of missing data in clinical trials and currently is a member a National Academy of Science committee that is addressing this issue. Dr. Scharfstein has been the lead statistician on a number of randomized and observational studies, including the Healthy Steps for Young Children Program, Guided Care, National Study of the Costs and Outcomes of Trauma, and the High Frequency Oscillation Ventilation Trial. Since 2003, he has been a member of the NIAID Therapeutics Trials Data Safety Monitoring Board and has served on a number of industry-sponsored DSMBs. He is a 2009 Fellow of the American Statistical Association and is the 1999 winner of the George W. Snedecor award for best paper in Biometry.