METRC will initially focus its efforts on research relevant to the early, acute treatment of major limb trauma. Over time, the Consortium will leverage its infrastructure to address other priority topics of relevance to both the acute care and rehabilitation of the wounded warrior and civilian trauma patient.


Priorities for investigation will be established in six core areas:

  • Bone Defect Reconstruction and Fracture Healing
  • Prevention and Treatment of Acute and Chronic Infections
  • Diagnosis and Treatment of Compartment Syndrome
  • Outcomes of Limb Salvage and Amputation
  • Post Acute Care and Rehabilitation Outcomes
  • Wound Care and Closure


    The primary objective of this study is to characterize the contemporary extremity wound “bioburden” at the time of definitive wound coverage or closure of severe extremity wounds employing new polymerase chain reaction PCR technology. We will also determine the relationship of subsequent infections to the initial bioburden screen as defined by both PCR technology and standard microbiology techniques.


    Read more about the BIOBURDEN study here.

    FIXIT Study

    This study will compare two standard options for treating severe open tibia fractures: internal fixation with a nail or plate and external ring fixation.


    Read more about the FIXIT study here.

    METALS II Study

    This study will provide a comprehensive longitudinal assessment of the clinical, functional and mental health consequences of major limb trauma and add to our understanding of the long-term benefits of reconstruction vs. amputation for the most severely injured. Importantly, we will be able to examine potential differences in care and outcomes for those injured earlier and later in OIF/OEF/OND to identify changes in care that may have influenced service use and outcomes.


    Read more about the METALS II study here.

    NERVE Study

    This study will collect information about the treatment of peripheral nerve injury (PNI) resulting from upper extremity trauma.


    Read more about the NERVE study here.