METRC – Major Extremity Trauma Research Consortium

Highlighted Papers

: Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial.
: Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET).
: Building a Clinical Research Network in Trauma Orthopaedics: The Major Extremity Trauma Research Consortium (METRC).
: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture.
: Modern External Ring Fixation Versus Internal Fixation for Treatment of Severe Open Tibial Fractures: A Randomized Clinical Trial (FIXIT Study).
: Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial.
: Outcomes Following Transtibial Amputation with and without a Tibiofibular Synostosis Procedure: A Multicenter Randomized Clinical Trial (TAOS Study).
: The Major Extremity Trauma Research Consortium: Development and Impact of an Orthopaedic Trauma Research Program.
: The Orthopaedic Trauma Association Open Fracture Classification Predicts Flap-Related Complications in Severe Open Tibial Fractures.

Journal Articles

O'Toole RV, Carlini AR, Schrank GM, O'Hara NN, Chung S, Gary JL, Obremskey W, Matuszewski PE, Teague D, Natoli RM, Degani Y, Collins SC, Howe AL, Thompson RE, Castillo RC: Topical antibiotic therapy to reduce infection after operative treatment of fractures at high risk of infection: TOBRA-a multicenter randomized controlled trial protocol.; OTA International; 2026; URL
Yoo JJ, Reider L, O'Hara NN, Bosse MJ, Gary JL, Morshed S, Potter BK, Quinnan SM, Castillo RC, Carlini AR, Firoozabadi R, Karunakar MA, O'Toole RV, Pensy RA, METRC: The Orthopaedic Trauma Association Open Fracture Classification Predicts Flap-Related Complications in Severe Open Tibial Fractures.; JOT; 2026; URL

Stewart CC, Reider L, Thompson AR, Scheffler AW, Namiri NK, Agel J, O'Toole RV, Karunakar MA, Potter BK, Bosse MJ, Morshed S: Time-Dependent Limb Assessment of High-Energy Lower Extremity Trauma Improves Prediction of Amputation: A Secondary Analysis of the OUTLET Study.; JBJS Open; 2025; URL
Levy JF, O'Toole RV, Stein DM, Haut ER, Frey KP, Castillo RC, O'Hara NN, METRC, NA NA, NA NA: Cost Savings of Switching to Aspirin for Thromboprophylaxis in Orthopaedic Trauma Patients: A Budget Impact Analysis.; JAAOS; 2025; URL
Schrank GM, O'Hara NN, Lee S, Degani Y, Chung S, Carlini AR, Castillo RC, O'Toole RV: Safety of topical tobramycin powder during operative treatment of fractures.; Journal of Antimicrobial Chemotherapy; 2025; URL
Levack AE, Reider L, Odum S, Hayda R, Frisch H, Andersen RC, Ficke JR, Bosse MJ: Outcomes of amputation and limb salvage in combat injuries: Does level of injury matter? A secondary analysis of Military Extremity Trauma Amputation/Limb Salvage (METALS) study data.; Injury; 2025; URL
Solarczyk J, Simske NM, Thompson AR, Reider L, Carroll EA, Gary JL, Castillo R, Quinnan SM, Obremskey W, O'Toole RV, Vallier HA, Morshed S, METRC: Functional Outcomes After Modern External Ring Fixation or Internal Fixation for Severe Open Tibial Shaft Fractures.; JBJS; 2025; URL
Major Extremity Trauma Research Consortium (METRC), Obremskey WT, O'Toole RV, Morshed S, Tornetta P, Murray CK, Jones CB, Scharfstein DO, Taylor TJ, Carlini AR, DeSanto JM, Castillo RC, Bosse MJ, Karunakar MA, Seymour RB, Sims SH, Weinrib DA, Churchill C, Carroll EA, Pilson HT, Goodman JB, Holden MB, Miller AN, Sietsema DL, Stahel PF, Mir H, Schmidt AH, Westberg JR, Mullis B, Shively KD, Hymes RA, Konda SR, Vallier HA, Breslin MA, Smith CS, Crickard CV, Reid JS, Baker M, Eglseder WA, LeBrun C, Manson T, Mascarenhas DC, Nascone J, Pollak AN, Schloss MG, Sciadini MF, Degani Y, Miclau T, Weiss DB, Yarboro SR, McVey ED, Firoozabadi R, Agel J, Burgos EJ, Gajari V, Rodriguez-Buitrago A, Tummuru RR, Trochez KM: Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial.; JAMA Surgery; 2025; URL
Stewart CC, Reider L, Soifer R, Namiri NK, O'Toole RV, Karunakar MA, Potter BK, Bosse M, Morshed S, METRC: What is the Surgical Burden of Treatment for High-Energy Lower Extremity Trauma? A Secondary Analysis of the OUTLET Study.; JOT; 2025; URL
Major Extremity Trauma Research Consortium (METRC): Outcomes Following Transtibial Amputation with and without a Tibiofibular Synostosis Procedure: A Multicenter Randomized Clinical Trial (TAOS Study).; JBJS; 2025; URL
Boissonneault A, O'Toole RV, Hayda R, Reid JS, Caroom C, Carlini A, Dagal A, Castillo R, Karunakar M, Matuszewski PE, Hymes R, O'Hara NN, METRC: Are Drains Associated With Infection After Operative Fixation of High-Risk Tibial Plateau and Pilon Fractures?; JOT; 2025; URL

Overmann AL, Carlini AR, O'Toole RV, Castillo RC, O'Hara NN: Predicting deep infection in pilon and tibial plateau fractures: a secondary analysis of the VANCO and OXYGEN trials.; OTA International; 2024; URL
Saiz AM, Carlini AR, Castillo RC, Joshi M, Huang Y, Murray CK, Bosse MJ, Dagal A, Gary JL, Karunakar MA, Weaver MJ, Obremskey W, McKinley TO, Altman GT, D'Alleyrand JG, Firoozabadi R, Collins SC, Agel J, Taylor TJ, Stall AC, Paryavi E, O'Hara NN, O'Toole RV, Warner SJ, METRC: Do the results of the OXYGEN trial change if analyzed as "as-treated?": A secondary analysis of the OXYGEN trial.; Injury; 2024; URL
Johnson DJ, O'Hara NN, Reider L, Gary JL, Obremskey W, Quinnan SM, Iii PT, Vallier HA, Carroll EA, O'Toole RV, METRC: Risk factors for infection in severe open tibial shaft fractures.; Injury; 2024; URL
Carlini AR, Agel J, Bosse MJ, Frey KP, Staguhn ED, Vallier HA, Obremskey W, Swiontkowski MF, Cannada LK, Tornetta P, MacKenzie EJ, O'Toole RV, Reider L, Allen LE, Collins SC, Castillo RC, METRC (Major Extremity Trauma Research Consortium): Minimal Clinically Important Difference (MCID) for the Short Musculoskeletal Function Assessment (SMFA) in Severe Lower Extremity Trauma: Pooled Data from 7 Multicenter, Prospective Clinical Trials.; JBJS; 2024; URL
Baumann ME, Haddad NR, Salazar A, Childers WL, Farrokhi S, Goldstein NB, Hendershot BD, Reider L, Thompson RE, Valerio MS, Dearth CL, Garza LA, Major Extremity Trauma Research Consortium (METRC): Testing the Reliability of Optical Coherence Tomography to Measure Epidermal Thickness and Distinguish Volar and Nonvolar Skin.; JID Innovations; 2024; URL
Major Extremity Trauma Research Consortium (METRC): Cognitive-Behavioral-Based Physical Therapy for Improving Recovery After a Traumatic Lower-Extremity Injury: The Results of a Randomized Controlled Trial.; JBJS; 2024; URL
Fram BR, Bosse MJ, Odum SM, Reider L, Gary JL, Gordon WT, Teague D, Alkhoury D, MacKenzie EJ, Seymour RB, Karunakar MA, The Major Extremity Trauma Research Consortium: Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma?: A Secondary Analysis of the OUTLET Study.; JBJS; 2024; URL
Major Extremity Trauma Research Consortium (METRC): The Bioburden Associated with Severe Open Tibial Fracture Wounds at the Time of Definitive Closure or Coverage: The BIOBURDEN Study.; JBJS; 2024; URL
Evans AR, Giannoudis PV, Leucht P, McKinley TO, Gaski GE, Frey KP, Wenke JC, Lee C: The local and systemic effects of immune function on fracture healing.; OTA International; 2024; URL
Firoozabadi R, Taylor TJ, Fernando N, Hsu JR, Stinner D, Obremskey W, Castillo RC, Major Extremity Trauma Research Consortium (METRC): Perioperative nutritional status thought to be important, but poorly understood.; European Journal of Orthopaedic Surgery & Traumatology; 2024; URL
O'Hara NN, Frey KP, Stein DM, Levy JF, Slobogean GP, Castillo R, Firoozabadi R, Karunakar MA, Gary JL, Obremskey WT, Seymour RB, Cuschieri J, Mullins CD, O'Toole RV, METRC: Effect of Aspirin Versus Low-Molecular-Weight Heparin Thromboprophylaxis on Medication Satisfaction and Out-of-Pocket Costs: A Secondary Analysis of a Randomized Clinical Trial.; JBJS; 2024; URL
Allen L, O'Toole RV, Bosse MJ, Obremskey WT, Archer KR, Cannada LK, Shores J, Reider LM, Frey KP, Carlini AR, Staguhn ED, Castillo RC: How many sites should an orthopedic trauma prospective multicenter trial have? A marginal analysis of the Major Extremity Trauma Research Consortium completed trials.; Trials; 2024; URL
Joshi M, O'Toole RV, Carlini AR, Gary JL, Obremskey WT, Murray CK, Gaski G, Reid JS, Degani Y, Taylor TJ, Collins SC, Huang Y, Whiting PS, Patterson JT, Lee OC, Castillo RC, METRC: Does Topical Vancomycin Powder Use in Fracture Surgery Change Bacteriology and Antibiotic Susceptibilities? An Analysis of the VANCO Trial.; JOT; 2024; URL
Gitajn IL, Werth PM, Carlini AR, Bosse MJ, Gary JL, Firoozabadi R, Obremskey W, McKinley TO, Castillo RC, O'Toole RV: Deep Surgical Site Infection after Fracture Has a Profound Effect on Functional Outcomes.; JBJS Open; 2024; URL
Reider L, Furgiuele D, Wan P, Schaffler B, Konda S, METRC (Major Extremity Trauma Research Consortium): Anesthetic Methods for Hip Fracture.; Current Osteoporosis Reports; 2024; URL
Patterson JT, Slobogean GP, Gary JL, Castillo RC, Firoozabadi R, Carlini AR, Joshi M, Allen LE, Huang Y, Bosse MJ, Obremskey WT, McKinley TO, Reid JS, O'Toole RV, O'Hara NN, and METRC: The VANCO Trial Findings Are Generalizable to a North American Trauma Registry.; JOT; 2024; URL
O'Hara NN, O'Toole RV, Frey KP, Castillo RC, Cuschieri J, Haut ER, Slobogean GP, Firoozabadi R, Christmas AB, Obremskey WT, Carlini AR, Gaski GE, Kutcher ME, Marvel D, Stein DM, Major Extremity Trauma Research Consortium (METRC): Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopedic trauma patients: A secondary analysis of the PREVENT CLOT trial.; JTACS; 2024; URL

Reider L, Owen EC, Dreyer HC, Fitton LS, Willey MC, METRC (Major Extremity Trauma Research Consortium): Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation.; Current Osteoporosis Reports; 2023; URL
The Major Extremity Trauma Research Consortium (METRC): The Major Extremity Trauma Research Consortium: Development and Impact of an Orthopaedic Trauma Research Program.; JAAOS; 2023; URL
Major Extremity Trauma Research Consortium (METRC): Development of a prosthetic fit and alignment assessment (ProFit) in persons with post-traumatic transtibial amputation.; Prosthetics and Orthotics International; 2023; URL
Renninger CH, Tedesco NS, Strelzow J: American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Prevention of Surgical Site Infections After Major Extremity Trauma.; Publish to Web Only; 2023; URL
Major Extremity Trauma Research Consortium (METRC), O'Toole RV, Stein DM, O'Hara NN, Frey KP, Taylor TJ, Scharfstein DO, Carlini AR, Sudini K, Degani Y, Slobogean GP, Haut ER, Obremskey W, Firoozabadi R, Bosse MJ, Goldhaber SZ, Marvel D, Castillo RC: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture.; NEJM; 2023; URL
Strelzow J, Tedesco NS, Renninger CH: American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Prevention of Surgical Site Infections After Major Extremity Trauma.; Publish to Web Only; 2023; URL
Patterson JT, O'Hara NN, Scharfstein DO, Castillo RC, O'Toole RV, Firoozabadi R, METRC: Do superficial infections increase the risk of deep infections in tibial plateau and plafond fractures?; European Journal of Orthopaedic Surgery & Traumatology; 2023; URL
O'Hara NN, Castillo RC, Carlini AR, Joshi M, Murray CK, Allen LE, Huang Y, Gary JL, Bosse MJ, Obremskey WT, McKinley TO, Schmidt AH, O'Toole RV, and METRC: Application of Bayesian Methods to Help Interpret the VANCO Trial Results.; JOT; 2023; URL

Patzkowski JC, Patzkowski MS: A Case Illustrating the Practical Application of the AAOS Clinical Practice Guideline: Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery.; Publish to Web Only; 2022; URL
Major Extremity Trauma Research Consortium (METRC): Modern External Ring Fixation Versus Internal Fixation for Treatment of Severe Open Tibial Fractures: A Randomized Clinical Trial (FIXIT Study).; JBJS; 2022; URL
Major Extremity Trauma Research Consortium (METRC): Effect of Supplemental Perioperative Oxygen on SSI Among Adults with Lower-Extremity Fractures at Increased Risk for Infection: A Randomized Clinical Trial.; JBJS; 2022; URL
Won NY, Paul A, Garibaldi M, Baumgartner RE, Kaufman KR, Reider L, Wrigley J, Morshed S: Scoping review to evaluate existing measurement parameters and clinical outcomes of transtibial prosthetic alignment and socket fit.; Prosthetics and Orthotics International; 2022; URL
Levy JF, Reider L, Scharfstein DO, Pollak AN, Morshed S, Firoozabadi R, Archer KR, Gary JL, O'Toole RV, Castillo RC, Quinnan SM, Kempton LB, Jones CB, Bosse MJ, MacKenzie EJ, METRC: The 1-Year Economic Impact of Work Productivity Loss Following Severe Lower Extremity Trauma.; JBJS; 2022; 10; https://doi.org/10.2106/jbjs.21.00632; URL
Obremskey WT, Tornetta P, Luly J, Morshed S, O'Toole RV, Hsu JR, Mitchell SL, Mackenzie EJ, Frey KP, Castillo RC, Bosse MJ, Scharfstein DO, METRC: Outcomes of Patients With Large Versus Small Bone Defects in Open Tibia Fractures Treated With an Intramedullary Nail: A Descriptive Analysis of a Multicenter Retrospective Study.; JOT; 2022; URL
Carlini AR, Collins SC, Staguhn ED, Frey KP, O'Toole RV, Archer KR, Obremskey WT, Agel J, Kleweno CP, Morshed S, Weaver MJ, Higgins TF, Bosse MJ, Levy JF, Wu AW, Castillo RC, METRC: Streamlining Trauma Research Evaluation With Advanced Measurement (STREAM) Study: Implementation of the PROMIS Toolbox Within an Orthopaedic Trauma Clinical Trials Consortium.; JOT; 2022; URL
Leroux A, Frey KP, Crainiceanu CM, Obremskey WT, Stinner DJ, Bosse MJ, Karunakar MA, O'Toole RV, Carroll EA, Hak DJ, Hayda R, Alkhoury D, Schmidt AH, METRC: Defining Incidence of Acute Compartment Syndrome in the Research Setting: A Proposed Method From the PACS Study.; JOT; 2022; URL
Castillo RC, Carlini AR, Chaffee T, Bosse MJ, O'Toole RV, Kleweno CP, McKinley TO, Agel J, Higgins TF, Morshed S, Staguhn ED, Aaron RV, Reider L, Wu AW, MacKenzie EJ, METRC: Long-Term Consequences of Major Extremity Trauma: A Pilot Study.; JOT; 2022; URL
McKinley TO, Gaski GE, Billiar TR, Vodovotz Y, Brown KM, Elster EA, Constantine GM, Schobel SA, Robertson HT, Meagher AD, Firoozabadi R, Gary JL, O'Toole RV, Aneja A, Trochez KM, Kempton LB, Steenburg SD, Collins SC, Frey KP, Castillo RC, METRC: Patient-Specific Precision Injury Signatures to Optimize Orthopaedic Interventions in Multiply Injured Patients (PRECISE STUDY).; JOT; 2022; URL
Stinner DJ, Rivera JC, Smith CS, Weiss DB, Hymes RA, Matuszewski PE, Gary JL, Morshed S, Schmidt AH, Wilken JM, Archer KR, Bailey L, Kleihege J, McLaughlin KH, Thompson RE, Chung S, Remenapp C, MacKenzie EJ, Reider L, METRC: Early Advanced Weight-Bearing After Periarticular Fractures: A Randomized Trial Comparing Antigravity Treadmill Therapy Versus Standard of Care.; JOT; 2022; URL
Archer KR, Davidson CA, Alkhoury D, Vanston SW, Moore TL, Deluca A, Betz JF, Thompson RE, Obremskey WT, Slobogean GP, Melton DH, Wilken JM, Karunakar MA, Rivera JC, Mir HR, McKinley TO, Frey KP, Castillo RC, Wegener ST, METRC: Cognitive-Behavioral-Based Physical Therapy for Improving Recovery After Traumatic Orthopaedic Lower Extremity Injury (CBPT-Trauma).; JOT; 2022; 36; Suppl 1; S1-S7; https://doi.org/10.1097/bot.0000000000002283; URL
McLaughlin KH, Mitchell SL, Archer KR, Master H, Morshed S, Gary JL, Jones CB, MacKenzie EJ, Reider L, METRC: Effect of Severe Distal Tibia, Ankle, and Mid- to Hindfoot Trauma on Meeting Physical Activity Guidelines 18 Months After Injury.; Archives of PM&R; 2022; URL

Major Extremity Trauma Research Consortium (METRC): Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET).; JBJS; 2021; URL
O'Toole RV, Stein DM, Frey KP, O'Hara NN, Scharfstein DO, Slobogean GP, Taylor TJ, Haac BE, Carlini AR, Manson TT, Sudini K, Mullins CD, Wegener ST, Firoozabadi R, Haut ER, Bosse MJ, Seymour RB, Holden MB, Gitajn IL, Goldhaber SZ, Eastman AL, Jurkovich GJ, Vallier HA, Gary JL, Kleweno CP, Cuschieri J, Marvel D, Castillo RC, METRC: PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients.; BMJ Open; 2021; URL
Major Extremity Trauma Research Consortium (METRC), O'Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Huang Y, Scharfstein DO, O'Hara NN, Gary JL, Bosse MJ, Castillo RC, Bishop JA, Weaver MJ, Firoozabadi R, Hsu JR, Karunakar MA, Seymour RB, Sims SH, Churchill C, Brennan ML, Gonzales G, Reilly RM, Zura RD, Howes CR, Mir HR, Wagstrom EA, Westberg J, Gaski GE, Kempton LB, Natoli RM, Sorkin AT, Virkus WW, Hill LC, Hymes RA, Holzman M, Malekzadeh AS, Schulman JE, Ramsey L, Cuff JAN, Haaser S, Osgood GM, Shafiq B, Laljani V, Lee OC, Krause PC, Rowe CJ, Hilliard CL, Morandi MM, Mullins A, Achor TS, Choo AM, Munz JW, Boutte SJ, Vallier HA, Breslin MA, Frisch HM, Kaufman AM, Large TM, LeCroy CM, Riggsbee C, Smith CS, Crickard CV, Phieffer LS, Sheridan E, Jones CB, Sietsema DL, Reid JS, Ringenbach K, Hayda R, Evans AR, Crisco MJ, Rivera JC, Osborn PM, Kimmel J, Stawicki SP, Nwachuku CO, Wojda TR, Rehman S, Donnelly JM, Caroom C, Jenkins MD, Boulton CL, Costales TG, LeBrun CT, Manson TT, Mascarenhas DC, Nascone JW, Pollak AN, Sciadini MF, Slobogean GP, Berger PZ, Connelly DW, Degani Y, Howe AL, Marinos DP, Montalvo RN, Reahl GB, Schoonover CD, Schroder LK, Vang S, Bergin PF, Graves ML, Russell GV, Spitler CA, Hydrick JM, Teague D, Ertl W, Hickerson LE, Moloney GB, Weinlein JC, Zelle BA, Agarwal A, Karia RA, Sathy AK, Au B, Maroto M, Sanders D, Higgins TF, Haller JM, Rothberg DL, Weiss DB, Yarboro SR, McVey ED, Lester-Ballard V, Goodspeed D, Lang GJ, Whiting PS, Siy AB, Obremskey WT, Jahangir AA, Attum B, Burgos EJ, Molina CS, Rodriguez-Buitrago A, Gajari V, Trochez KM, Halvorson JJ, Miller AN, Goodman JB, Holden MB, McAndrew CM, Gardner MJ, Ricci WM, Spraggs-Hughes A, Collins SC, Taylor TJ, Zadnik M: Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial.; JAMA Surgery; 2021; URL
Coe MP, Osborn CPM, Schmidt AH: AAOS Clinical Practice Guideline: Management of Acute Compartment Syndrome.; Publish to Web Only; 2021; URL
O'Toole RV, Degani Y, Carlini AR, Castillo RC, O'Hara NN, Joshi M, and METRC: Systemic Absorption and Nephrotoxicity Associated With Topical Vancomycin Powder for Fracture Surgery.; JOT; 2021; URL

Reider L, Bai J, Scharfstein DO, Zipunnikov V, for METRC OUTLET Study Investigators: Methods for Step Count Data: Determining "Valid" Days and Quantifying Fragmentation of Walking Bouts.; Gait and Posture; 2020; URL
Schmidt AH, Di J, Zipunnikov V, Frey KP, Scharfstein DO, O'Toole RV, Bosse MJ, Obremskey WT, Stinner DJ, Hayda R, Karunakar MA, Hak DJ, Carroll EA, Collins SCJ, MacKenzie EJ, METRC: Perfusion Pressure Lacks Diagnostic Specificity for the Diagnosis of Acute Compartment Syndrome.; JOT; 2020; URL
Gitajn IL, Reider L, Scharfstein DO, O'Toole RV, Bosse MJ, Castillo RC, Jevsevar DS, Pollak AN, METRC: Variability in Discharge Disposition Across US Trauma Centers After Treatment for High-Energy Lower Extremity Injuries.; JOT; 2020; URL

Major Extremity Trauma Rehabilitation Consortium (METRC): Early Effects of the Trauma Collaborative Care Intervention: Results From a Prospective Multicenter Cluster Clinical Trial.; JOT; 2019; URL
O'Hara NN, Degani Y, Marvel D, Wells D, Mullins CD, Wegener S, Frey K, Joseph T, Hurst J, Castillo R, O'Toole RV, PREVENT CLOT Stakeholder Committee: Which orthopaedic trauma patients are likely to refuse to participate in a clinical trial? A latent class analysis.; BMJ Open; 2019; URL
Major Extremity Trauma Research Consortium (METRC): A Randomized Controlled Trial Comparing rhBMP-2/Absorbable Collagen Sponge Versus Autograft for the Treatment of Tibia Fractures With Critical Size Defects.; JOT; 2019; URL
Mitchell SL, Obremskey WT, Luly J, Bosse MJ, Frey KP, Hsu JR, MacKenzie EJ, Morshed S, O'Toole RV, Scharfstein DO, Tornetta P, Major Extremity Trauma Rehabilitation Consortium (METRC): Inter-Rater Reliability of the Modified Radiographic Union Score for Diaphyseal Tibial Fractures With Bone Defects.; JOT; 2019; URL
Castillo RC, Huang Y, Scharfstein D, Frey K, Bosse MJ, Pollak AN, Vallier HA, Archer KR, Hymes RA, Newcomb AB, MacKenzie EJ, Wegener S, Major Extremity Trauma Research Consortium (METRC), Hsu JR, Karunakar MA, Seymour RB, Sims SH, Flores E, Churchill C, Hak DJ, Henderson CE, Mir HR, Chan DS, Shah AR, Steverson B, Westberg J, Gary JL, Achor TS, Choo A, Munz JW, Porrey M, Hendrickson S, Breslin MA, McKinley TO, Gaski GE, Kempton LB, Sorkin AT, Virkus WW, Hill LC, Jones CB, Sietsema DL, O'Toole RV, Ordonio K, Howe AL, Zerhusen TJ, Obremskey W, Boyce RH, Jahangir AA, Molina CS, Sethi MK, Vanston SW, Carroll EA, Drye DY, Holden MB, Collins SC, Wysocki E: Association Between 6-Week Postdischarge Risk Classification and 12-Month Outcomes After Orthopedic Trauma.; JAMA Surgery; 2019; URL

Potter BK, Sheu RG, Stinner D, Fergason J, Hsu JR, Kuhn K, Owens JG, Rivera J, Shawen SB, Wilken JM, DeSanto J, Huang Y, Scharfstein DO, MacKenzie EJ: Multisite Evaluation of a Custom Energy-Storing Carbon Fiber Orthosis for Patients with Residual Disability After Lower-Limb Trauma.; JBJS; 2018; URL
Schmidt AH, Bosse MJ, Obremskey WT, O'Toole RV, Carroll EA, Stinner DJ, Hak DJ, Karunakar M, Hayda R, Frey KP, Di J, Zipunnikov V, MacKenzie E, Major Extremity Trauma Research Consortium (METRC): Continuous Near-Infrared Spectroscopy Demonstrates Limitations in Monitoring the Development of Acute Compartment Syndrome in Patients with Leg Injuries.; JBJS; 2018; URL

Wegener ST, Carroll EA, Gary JL, McKinley TO, O'Toole RV, Sietsema DL, Castillo RC, Frey KP, Scharfstein DO, Huang Y, Collins SCJ, MacKenzie EJ, Major Extremity Trauma Research Consortium (METRC): Trauma Collaborative Care Intervention: Effect on Surgeon Confidence in Managing Psychosocial Complications After Orthopaedic Trauma.; JOT; 2017; URL
Wegener ST, Pollak AN, Frey KP, Hymes RA, Archer KR, Jones CB, Seymour RB, O'Toole RV, Castillo RC, Huang Y, Scharfstein DO, MacKenzie EJ, METRC: The Trauma Collaborative Care Study (TCCS).; JOT; 2017; URL
Castillo RC, Raja SN, Frey KP, Vallier HA, Tornetta P, Jaeblon T, Goff BJ, Gottschalk A, Scharfstein DO, O'Toole RV, METRC: Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study).; JOT; 2017; URL
Bosse MJ, Morshed S, Reider L, Ertl W, Toledano J, Firoozabadi R, Seymour RB, Carroll E, Scharfstein DO, Steverson B, MacKenzie EJ, METRC: Transtibial Amputation Outcomes Study (TAOS): Comparing Transtibial Amputation With and Without a Tibiofibular Synostosis (Ertl) Procedure.; JOT; 2017; URL
Hsu JR, Owens JG, DeSanto J, Fergason JR, Kuhn KM, Potter BK, Stinner DJ, Sheu RG, Waggoner SL, Wilken JM, Huang Y, Scharfstein DO, MacKenzie EJ, METRC: Patient Response to an Integrated Orthotic and Rehabilitation Initiative for Traumatic Injuries: The PRIORITI-MTF Study.; JOT; 2017; URL
Bosse MJ, Teague D, Reider L, Gary JL, Morshed S, Seymour RB, Toledano J, Cannada LK, Steverson B, Scharfstein DO, Luly J, MacKenzie EJ, METRC: Outcomes After Severe Distal Tibia, Ankle, and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation (OUTLET).; JOT; 2017; URL
Schmidt AH, Bosse MJ, Frey KP, O'Toole RV, Stinner DJ, Scharfstein DO, Zipunnikov V, MacKenzie EJ, METRC: Predicting Acute Compartment Syndrome (PACS): The Role of Continuous Monitoring.; JOT; 2017; URL
Obremskey WT, Schmidt AH, O'Toole RV, DeSanto J, Morshed S, Tornetta P, Murray CK, Jones CB, Scharfstein DO, Taylor TJ, Carlini AR, Castillo RC, METRC: A Prospective Randomized Trial to Assess Oral Versus Intravenous Antibiotics for the Treatment of Postoperative Wound Infection After Extremity Fractures (POvIV Study).; JOT; 2017; URL
O'Toole RV, Joshi M, Carlini AR, Sikorski RA, Dagal A, Murray CK, Weaver MJ, Paryavi E, Stall AC, Scharfstein DO, Agel J, Zadnik M, Bosse MJ, Castillo RC, METRC: Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High-Energy Fracture Surgery (OXYGEN Study).; JOT; 2017; URL
O'Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Scharfstein DO, Gary JL, Bosse MJ, Castillo RC, METRC: Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter, Randomized, Controlled Trial (VANCO Study).; JOT; 2017; URL
O'Toole RV, Gary JL, Reider L, Bosse MJ, Gordon WT, Hutson J, Quinnan SM, Castillo RC, Scharfstein DO, MacKenzie EJ, METRC: A Prospective Randomized Trial to Assess Fixation Strategies for Severe Open Tibia Fractures: Modern Ring External Fixators Versus Internal Fixation (FIXIT Study).; JOT; 2017; URL
Bosse MJ, Murray CK, Carlini AR, Firoozabadi R, Manson T, Scharfstein DO, Wenke JC, Zadnik M, Castillo RC, METRC: Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage: Correlation With Subsequent Postclosure Deep Wound Infection (Bioburden Study).; JOT; 2017; URL
Stinner DJ, Wenke JC, Ficke JR, Gordon W, Toledano J, Carlini AR, Scharfstein DO, MacKenzie EJ, Bosse MJ, Hsu JR, Major Extremity Trauma Research Consortium (METRC): Military and Civilian Collaboration: The Power of Numbers.; Military Medicine; 2017; URL

Major Extremity Trauma Research Consortium (METRC): Building a Clinical Research Network in Trauma Orthopaedics: The Major Extremity Trauma Research Consortium (METRC).; JOT; 2016; URL
Manson TT, Reider L, O'Toole RV, Scharfstein DO, Tornetta P, Gary JL, Major Extremity Trauma Research Consortium (METRC): Variation in Treatment of Displaced Geriatric Acetabular Fractures Among 15 Level-I Trauma Centers.; JOT; 2016; URL

Castillo RC, Mackenzie EJ, Bosse MJ, METRC Investigators: Measurement of functional outcomes in the Major Extremity Trauma Research Consortium (METRC).; JAAOS; 2014; URL

Posters and Presentations

PO vs IV Antibiotics for Fracture Related Infections: A Bayesian Analysis
AAST: Poster FINDINGS OF THE PREVENT CLOT MULTICENTER RANDOMIZED CLINICAL TRIAL ARE GENERALIZABLE TO A NATIONAL TRAUMA DATASET
Canadian Ortho Association Shock Volume Predicts Venous Thromboembolism and Bleeding Complications Following Orthopaedic Polytrauma
Antibiotic Treatment Compliance Among Patients with Fracture Related Infections: A Secondary Analysis of the POvIV trial
The Combination of MCP-1, IL-9 and IL-10 on Admission Identifies Diverging Outcomes Across Diverse Cohorts of Polytrauma Patients
Culture positivity in open fractures is an indicator of bacterial bioburden
Leveraging Theory and Patient Input to Improve Implementation of a Clinical Practice Guideline for Psychosocial Screening following Orthopaedic Trauma
Modern External Ring Fixation Versus Internal Fixation for Treatment of Severe Open Tibial Fractures: An Observational Trial
FIXIT Pain Outcomes: PDF
The Relationship Between Age and Infection in Orthopedic Trauma: A Secondary Analysis of Four Multicenter Studies Including 14,500 Patients
Are outcomes of type III open calcaneus fractures superior to early amputation at 18 months?
Does the Sinus Tarsi Approach for Calcaneal Fractures Really Confer any Infection Protection?
Antibiotic Powder Associated With Delayed Presentation of Deep Surgical Site Infection for Pilon and Plateau Fractures: A Secondary Analysis of the VANCO and OXYGEN Studies
Differences in Patients, Injuries and Outcomes Between Large and Small Enrolling Centers in the VANCO & OXYGEN Trials
Risk factors prediction of treatment failure and recurrent infection in patients with Fracture Related Infections
Western Orthopaedic Association 89th Annual Meeting Limbo 2 - Dynamic Limb Assessment of High-Energy Lower Extremity Trauma Improves Prediction of Amputation
No Difference in Treatment Failure with Debridement, Antibiotics, and Implant Retention (DAIR) versus Debridement, Antibiotics, and Fixation Revision (DAFR) for the Treatment of Fracture-Related Infections (FRIs)
Understanding the Differences Between ITT and Per-Protocol Results in Randomized Trials
Immune Trajectories In Polytrauma Patients with Organ Dysfunction
"Shock Volume Predicts Venous Thromboembolism and Bleeding Complications Following Orthopaedic Polytrauma"
Deficient Epithelial and Adaptive Immunologic Mediators Associate with Organ Dysfunction in Patients with Lower-Magnitude Injuries Treated with Early Total Care
Trauma-induced hemorrhage orchestrates a distinct inflammatory response in polytrauma patients with major fractures
Do Thromboembolic Events Differ by Prophylaxis Type in Patients with Orthopaedic Trauma Based on Inpatient vs Outpatient Setting? A Secondary Analysis of the PREVENT CLOT Data
Timing of Venous Thromboembolic Events and Mortality Following Orthopaedic Trauma
Determining Venous Thromboembolic and Pulmonary Embolism Risk in Orthopaedic Trauma Patients
Assessing the Impact of Site VTE Practice Variation on a Multicenter RCT Comparing Aspirin and LMWH for Mortality Prevention: A Secondary Analysis of PREVENT CLOT Study: PDF
Longitudinal Relationships Between Pain, Depression, Anxiety, and Physical Function After Severe Extremity Fractures
Minimally Clinically Important Difference (MCID) and Effect Sizes (ES) for PROMIS Physical Health Domains in Lower Extremity Trauma
TOBRA Main Results
A Prospective Randomized Trial to Assess Early versus Delayed Weight Bearing Following Operatively Treated Ankle Fractures in the United States

Shock Volume May Serve as an Early Predictor of Venous Thrombembolism Complications Following Orthopaedic Polytrauma
Stem Cell Pilot
EMS bind main results
FIXIT mental health (RCT+ OBS)
FIXIT PRO (RCT): PDF
prevent clot societal cost
PCLOT Subgroup analysis
Shock Volume May Serve as an Early Predictor of Organ Dysfunction in Orthopaedic Polytrauma
Organ Dysfunction Corresponds to Number of Destabilizing Axial and Appendicular Fractures in Polytraumatized Patients
TMR/RPNI survey
Tobra safety study
RABG analysis
Outcomes following treatment of open pilon fractures
Pseudofactorial study
vanco cost effectiveness
REPAIR- main results
Thrombelastography as a Predictive Tool for Thromboembolic Events After Extremity Trauma: A Prospective Secondary Analysis of PREVENT-CLOT
Antibiotic treatment compliance among patients with fracture-related infections in Orthopaedic trauma setting.

Impact of Surgeon Experience on Major Complications after Ring Fixator Treatment of Severe Open Tibia Fractures
Physical and Mental Health Effects Diagnosed in Military Service Members following Severe Combat Extremity Trauma (METALS 2)
A Randomized Trial Comparing Anti-Gravity Treadmill Therapy versus Standard of Care: It's Safe and Patients Like It
SAVIT, a Novel Risk Score Based on the OTA Open Fracture Classification, Predicts Limb Salvage after Severe Open Tibia Fractures
Time-dependent domains of the OTA open fracture classification predict decision to amputate in severe ankle and hindfoot injuries
Do Some Patients Benefit More From Vanco powder? Heterogenous Treatment Effects in the VANCO trial
Concordance between Traditional Culture and Next Generation Sequencing: PDF
The VANCO Trial Findings Are Generalizable to a North American Trauma Registry
Risk Factors for Infection in Severe Open Tibial Shaft Fractures
Are Drains Associated With Infection After Operative Fixation Of High-Risk Tibial Plateau And Pilon Fractures?
Risk-Stratified Thromboprophylaxis Effects of Aspirin Versus Low-Molecular-Weight Heparin in Orthopaedic Trauma Patients
Patient Satisfaction and Out-of-Pocket Costs Associated with Aspirin and Low-Molecular-Weight Heparin: A Secondary Analysis of the PREVENT CLOT study
Microbial interspecies associations in open fracture and subsequent infection using Next Generation Sequencing: PDF
AlterG Main Results
The impact of the Single IRB on the optimal number of sites in multicenter trials in orthopaedic trauma
Long-term Functional Outcomes Following Major Lower Limb Trauma Sustained in the Military (METALS 1 )
Modern External Ring Fixation Versus Internal Fixation in Severe Open Tibia Fractures Treated by Surgeons with Prior Ring Experience
Does Size Really Matter? Differences in Patients, Injuries and Outcomes Between Large and Small Enrolling Centers in the VANCO & OXYGEN Trials.
Do patients with Orthopaedic Trauma Experience a lower Perceived Ability to Participate in Social Roles and Activities and is there a relationship between their perceived ability and physical reported outcomes?
Applied Cognition Following Orthopaedic Trauma
Deep Surgical Site Infection after Fracture has a Profound Effect on Functional Outcome
Increased Operative Time Does Not Increase Deep Infection Rates In Closed Bicondylar Tibial Plateaus Treated With Dual Plating
The OTA-Open Fracture Classification (OTA-OFC) Predicts Flap-Related Complications in Severe Open Tibial Fractures?
Next-generation Sequencing Results Suggest that a Change in Antibiotic Prophylaxis in Severe Open Tibia Fractures is Warranted
Does Objective Data Change the Diagnosis of Acute Compartment Syndrome (ACS) in Patients with Tibia Fractures?
A Multifactorial Crosswalk Between the SMFA and a Five Item PROMIS Item Bank Set.
Variability in Treatment of Upper Extremity Peripheral Nerve Injuries Across 17 US Trauma Centers

Obremskey WT, O'Toole RV, Morshed S, Tornetta P 3rd, Murray CK, Jones CB, Scharfstein DO, Taylor TJ, Carlini AR, DeSanto JM, Castillo RC and METRC. A prospective randomized trial to assess oral (PO) versus intravenous (IV) antibiotics for the treatment of post-op wound infection after extremity fractures (POvIV): A randomized controlled trial. [Abstract, podium presentation] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.
O'Hara NN, Castillo RC, Carlini AR, Huang Y, Bosse MJ, Obremskey WT, Gary JL, Joshi M, O'Toole RV, METRC VANCO Study. Predicting deep surgical site infections in high-risk tibial plateau and pilon fracture: A secondary analysis of the VANCO trial. [Abstract, poster] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.
O'Toole RV, Joshi M, Carlini AR, Huang Y, Murray CM, Bosse MJ, Scharfstein DO, Dagal A, Gary JL, Karunakar M, Weaver MJ, Obremskey WT, McKinley T, Altman G, Sen M, D'Alleyrand JC, Degani Y, Collins SC, Agel J, Taylor TJ, Sikorski R, Stall A, Paryavi E, Holmes A, Zadnik M, Castillo RC, METRC OXYGEN Study. Supplemental perioperative oxygen to reduce surgical site infection after high-energy fracture surgery (OXYGEN study). [Abstract, podium presentation] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.
Firoozabadi R, O'Hara NN, Joshi M, Murray CM, Reid JS, Gaski G, Carlini AR, Huang Y, Scharfstein DO, O'Toole RV, Castillo RC, METRC VANCO Study. Do superficial surgical site infections lead to deep surgical site infections after fracture surgery: A secondary analysis of the VANCO trial. [Abstract, poster] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.
Gary JL, Slobogean G, Kleweno CP, Tornetta P, Bosse MJ, Luly J, Carlini AR, Scharfstein DO, Sagi HC, Castillo RC and METRC. A Multicenter Retrospective Review of Pre-Hospital and Emergent Management of Volume Expanding Pelvic Ring Disruption: An Opportunity for Improvement?. [Podium presentation] Submitted to SOMOS/OTA/AOSSM/ASSH Extremity War Injuries XV. 2020.

O'Toole RV, Joshi M, Carlini AR, Gary JL, Obremskey WT, Murray C, Gaski G, Reid JS, Degani Y, Taylor TJ, Collins SC, Huang Y, Scharfstein DO, Castillo RC, METRC VANCO Study. Does topical vancomycin powder use in fracture surgery change bacteriology and antibiotic susceptibilities? An analysis of the VANCO trial. [Abstract, podium presentation] Submitted to the 34th Annual Meeting of the Orthopaedic Trauma Association. 2019. *Selected as Highlight Paper.
Murray CK, Yun HC, Joshi M, Carlini AR, Castillo RC, Bosse MJ and METRC Bioburden The efficacy of antibiotic strategies employed at the time of definitive wound closure/coverage for severe lower extremity injuries. [Abstract, podium presentation] Submitted to the 34th Annual Meeting of the Orthopaedic Trauma Association. 2019.

O'Toole RV, Degani Y, Carlini AR, Castillo RC, Joshi M, METRC. Systemic absorption and nephrotoxicity associated with topical vancomycin powder for fracture surgery. [Abstract, podium presentation] Submitted to the 33nd Annual Meeting of the Orthopaedic Trauma Association. 2018.
Castillo RC, Carlini AR, Frey KP, O'Toole RV, Archer KR, Obremskey WT, Agel J, Kleweno CP, Morshed SA, Weaver MJ, Higgins TF, Bosse MJ, Collins SC, Wegener ST, Wu AW, Chan KS and METRC. PROMIS PF and SMFA crosswalk: Accuracy varies by domain. [Abstract, poster] Submitted to the Military Health System Research Symposium (MHSRS). 2018.: PDF
Carlini AR, Frey KP, Kirk R, Collins SC, O'Toole RV, Archer KR, Obremskey WT, Agel J, Kleweno CP, Morshed SA, Weaver MJ, Higgins TF, Bosse MJ, Chan KS, Wu AW, Castillo RC and METRC. Implementation of the PROMIS toolbox within an orthopaedic trauma clinical trials consortium. [Abstract, poster] Submitted to the Military Health System Research Symposium (MHSRS). 2018.: PDF
O'Toole RV, Joshi M, Carlini AR, Gary JL, Obremskey WT, Murray CK, Gaski G, Reid JS, Degani Y, Taylor TJ, Collins SC, Huang Y, University of Maryland at Baltimore School Medicine; METRC; Castillo RC. A multicenter randomized trial evaluating intrawound vancomycin powder for reducing surgical site infection after fracture surgery. [Abstract, podium presentation] Submitted to the 33nd Annual Meeting of the Orthopaedic Trauma Association. 2018.

Castillo RC. The STREAM Study: Streamlining Trauma Research Evaluation with Advanced Measurement. Submitted to the ACRM 94th Annual Conference [podium presentation]. 2017.

Firoozabadi R, Castillo RC, O'Toole RV, Carlini AR, Bosse MJ and METRC. Clinically important subgroups within a large cohort of Gustilo Type IIIB open tibia fractures: An analysis of surgical re-hospitalizations. [Abstract] Submitted to the Military Health System Research Symposium. 2016.
Castillo RC, Bosse MJ, Morshed SA, Higgins TF, Archer KR, Agel J, Wu AW, O'Toole RV, Carlini AR, Frey KP, Kirk R, Wegener ST and METRC. Sleep Disturbance Following Orthopaedic Trauma - Does it Predict Future Physical Functioning?. [Abstract, poster] Submitted to the 31st Annual Meeting of the Orthopaedic Trauma Association. 2016.: PDF

Bosse MJ and the METRC Investigators. Correlation between Routine Microbiology Results at Definitive Closure and Wound Infection in Type III Tibia Fractures: Results from a Multi-Center, Prospective Cohort Study. [Abstract] Submitted to the 30th Annual Meeting of the Orthopaedic Trauma Association. 2015.: PDF
Bosse MJ and the METRC Investigators. How scary is this? Characterizing Antibiotic Use for Type III Tibia Fractures. [Abstract] Submitted to the 30th Annual Meeting of the Orthopaedic Trauma Association. 2015.: PDF
Stinner DJ, Wenke JC, Ficke JR, Gordon W, Toledano J, Carlini AR, Andersen R, Hsu JR and the METRC Investigators. Military and Civilian Collaboration: The Power of Numbers. [Abstract] Submitted to the Military Health System Research Symposium. 2015.
Ballreich J, deLissovoy G, Allen L, Reider L, Frey K, Carlini A, Castillo R, MacKenzie E. Projecting Enrollment Across Multiple Studies in a Clinical Trials Consortium: A Forecasting Tool. [Abstract] Submitted to the 51st Annual Meeting of the Drug Information Association. 2015.

METRC Investigators. Identifying Enrollment Challenges and Discovering Research Opportunities in an Orthopaedic Trauma Consortium: The Value of a "Start-up" Registry. [Scientific Poster #119] Submitted to the 28th Annual Meeting of the Orthopaedic Trauma Association. 2012.: PDF
METRC Investigators. "Apples-to-Apples" - Moving to the New OTA Fracture Severity Classification in Extremity Trauma Research. [Scientific Poster #121] Submitted to the 28th Annual Meeting of the Orthopaedic Trauma Association. 2012.: PDF

Disparate Care Utilization for Rehabilitation of Severe Combat Sustained Extremity Trauma Drive by Limb Reconstruction (METALS 4)
Physical and Mental Health Effects Diagnosed in Military Service Members following Severe Combat Extremity Trauma (METALS 3)
Academic Surgical Congress-2026 "Inflammatory Mediators Connect Cumulative Hypoperfusion to Organ Dysfunction After Traumatic Injury"
Orthopedic Research Society-2026 "Differential Roles of Inflammatory Mediators in Organ Dysfunction After Osseous vs. Non-Osseous Injury"
2026 COA/CORS/CORA Annual Meeting: June 2026 Distinct Immunologic Mediators Are Associated with Venous Thromboembolism in Polytrauma Patients

Clinical Practice Guidelines & Appropriate Use Criteria

AUC Summary Paper: Early Screening for Psychosocial Risk Factors: URL
American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Prevention of Surgical Site Infections After Major Extremity Trauma.: URL
American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Prevention of Surgical Site Infections After Major Extremity Trauma.: URL
AUC Summary Paper: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
AUC: Prevention and Treatment of Surgical Site Infection: URL
CPG: Prevention and Treatment of Surgical Site Infection: URL
AUC Case Study Paper: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
A Case Illustrating the Practical Application of the AAOS Clinical Practice Guideline: Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery.: URL
CPG Summary Paper: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
AUC: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
CPG: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
AUC Case Study Paper: Early Screening for Psychosocial Risk Factors: URL
Appropriate Use Criteria (AUC) for the Limb Salvage or Early Amputation: URL
CPG Summary Paper: Early Screening for Psychosocial Risk Factors: URL
CPG Summary Paper: Limb Salvage or Early Limb Amputation: URL
AUC: Early Screening for Psychosocial Risk Factors: URL
AUC: Diagnosis and Treatment of Acute Compartment Syndrome: URL
AAOS Prevention of Surgical Site Infection After Extremity Trauma Guideline Summary: URL
2021 AAOS Clinical Practice Guideline Summary: Management of Acute Compartment Syndrome: URL
AAOS Clinical Practice Guideline: Management of Acute Compartment Syndrome.: URL
2021 AAOS Appropriate Use Criteria Summary: Diagnosis and Management of Acute Compartment Syndrome: URL
2018 AAOS/METRC CPG on Management of Acute Compartment Syndrome: URL
2019 AAOS/METRC CPG on Limb Salvage or Early Amputation: URL
2019 AAOS/METRC CPG on the Evaluation of Psychosocial Factors Influencing Recovery from Adult Orthopaedic Trauma: URL

Consortium Reports

METRC Publications & Presentations Guidelines

These documents can also be found on METRC’s Policy and Procedure Manual page found here.

METRC Publications & Presentations Guidelines: PDF
Appendix A - Defining the Research Group: PDF
Appendix B - Corporate Authorship Framework: PDF
Appendix C - Authorship Form: PDF
Appendix D - Conference Abstract Submission Checklist: PDF

METRCMajor Extremity Trauma Research Consortium

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