METRC – Major Extremity Trauma Research Consortium

Johnson DJ, O'Hara NN, Reider L, Gary JL, Obremskey W, Quinnan SM, Iii PT, Vallier HA, Carroll EA, O'Toole RV; METRC: Risk Factors for Infection in Severe Open Tibial Shaft Fractures; Injury; 2024; URL
Carlini AR, Agel J, Bosse MJ, Frey KP, Staguhn ED, Vallier HA, Obremskey W, Swiontkowski MF, Cannada LK, Tornetta P 3rd, MacKenzie EJ, O'Toole RV, Reider L, Allen LE, Collins SC, Castillo RC; METRC (Major Extremity Trauma Research Consortium): Minimal Clinically Important Difference (MCID) for the Short Musculoskeletal Functional Assessment (SMFA) in Patients with Severe Lower Extremity Fractures: Pooled Data from Seven Multicenter, Prospective Clinical Trials; JBJS; 2024; URL
Baumann ME, Haddad NR, Salazar A, Childers WL, Farrokhi S, Goldstein NB, Hendershot BD, Reider L, Thompson RE, Valerio MS, Dearth CL, Garza LA; Major Extremity Trauma Research Consortium (METRC).: Testing the Reliability of Optical Coherence Tomography to Measure Epidermal Thickness and Distinguish Volar and Non-Volar Skin; JID Innovations; 2024; URL
Major Extremity Trauma Research Consortium (METRC): Cognitive Behavioral Based Physical Therapy for Improving Recovery after Traumatic Lower Extremity Injury: Results from a Randomized Controlled Trial; JBJS; 2024; URL
Evans AR, Giannoudis PV, Leucht P, McKinley TO, Gaski GE, Frey KP, Wenke JC, Lee C.: The local and systemic effects of immune function on fracture healing; OTA International; 2024; URL
Firoozabadi R, Taylor TJ, Fernando N, Hsu JR, Stinner D, Obremskey W, Castillo RC; Major Extremity Trauma Research Consortium (METRC): Perioperative nutritional status thought to be important, but poorly understood; European Journal of Orthopaedic Surgery & Traumatology; 2024; URL
O'Hara NN, Frey KP, Stein DM, Levy JF, Slobogean GP, Castillo R, Firoozabadi R, Karunakar MA, Gary JL, Obremskey WT, Seymour RB, Cuschieri J, Mullins CD, O'Toole RV; METRC.: Effect of Aspirin Versus Low-Molecular-Weight Heparin Thromboprophylaxis on Medication Satisfaction and Out-of-Pocket Costs: A Randomized Clinical Trial Secondary Analysis; JBJS; 2024; URL
Allen L, O'Toole RV, Bosse MJ, Obremskey WT, Archer KR, Cannada LK, Shores J, Reider LM, Frey KP, Carlini AR, Staguhn ED, Castillo RC.: How many sites should an orthopaedic trauma prospective multicenter trial have? A marginal analysis of the Major Extremity Trauma Research Consortium completed trials; Trials; 2024; URL
Joshi M, O'Toole RV, Carlini AR, Gary JL, Obremskey WT, Murray CK, Gaski G, Reid JS, Degani Y, Taylor TJ, Collins SC, Huang Y, Whiting PS, Patterson JT, Lee OC, Castillo RC; METRC.: Does Topical Vancomycin Powder Use in Fracture Surgery Change Bacteriology and Antibiotic Susceptibilities? An Analysis of the VANCO Trial; JOT; 2024; URL
Gitajn IL, Werth PM, Carlini AR, Bosse MJ, Gary JL, Firoozabadi R, Obremskey W, McKinley TO, Castillo RC, O'Toole RV: Deep Surgical Site Infection after Fracture has a Profound Effect on Functional Outcome; JBJS Open; 2024; URL
Reider L, Furgiuele D, Wan P, Schaffler B, Konda S; and METRC (Major Extremity Trauma Research Consortium): Anesthesia Methods for Hip Fracture; Current Osteoporosis Reports; 2024; URL
Patterson JT, Slobogean GP, Gary JL, Castillo RC, Firoozabadi R, Carlini AR, Joshi M, Allen LE, Huang Y, Bosse MJ, Obremskey WT, McKinley TO, Reid JS, O'Toole RV, O'Hara NN; and METRC: The VANCO Trial Findings Are Generalizable to a North American Trauma Registry; JOT; 2024; URL
O'Hara NN, O'Toole RV, Frey KP, Castillo RC, Cuschieri J, Haut ER, Slobogean GP, Firoozabadi R, Christmas A, Obremskey WT, Carlini AR, Gaski G, Kutcher ME, Marvel D, Stein DM; Major Extremity Trauma Research Consortium (METRC): Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopaedic trauma patients: a secondary analysis of the PREVENT CLOT trial.; JTACS; 2024; URL

Reider L, Owen EC, Dreyer HC, Fitton LS, Willey MC; and METRC (Major Extremity Trauma Research Consortium): Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation; Current Osteoporosis Reports; 2023; URL
Major Extremity Trauma Research Consortium (METRC): Development of a prosthetic fit and alignment assessment (ProFit) in persons with post-traumatic transtibial amputation; Prosthetics and Orthotics International; 2023; URL
Major Extremity Trauma Research Consortium (METRC): Aspirin or low-molecular-weight heparin for thromboprophylaxis after a fracture; NEJM; 2023; URL

Patterson JT, O'Hara NN, Scharfstein DO, Castillo RC, O'Toole RV, Firoozabadi R; METRC: Do superficial infections increase the risk of deep infections in tibial plateau and plafond fractures?; European Journal of Orthopaedic Surgery & Traumatology; 2022; URL
Major Extremity Trauma Research Consortium (METRC): Modern External Ring Fixation Versus Internal Fixation for Treatment of Severe Open Tibial Fractures: A Randomized Clinical Trial (FIXIT Study); JBJS; 2022; URL
Major Extremity Trauma Research Consortium (METRC): Effect of Supplemental Perioperative Oxygen on SSI Among Adults with Lower-Extremity Fractures at Increased Risk for Infection: A Randomized Clinical Trial; JBJS; 2022; URL
Levy JF, Reider L, Scharfstein DO, Pollak AN, Morshed S, Firoozabadi R, Archer KR, Gary JL, O'Toole RV, Castillo RC, Quinnan SM, Kempton LB, Jones CB, Bosse MJ, MacKenzie EJ; METRC: The 1-Year Economic Impact of Work Productivity Loss Following Severe Lower Extremity Trauma; JBJS; 2022; 10; https://doi.org/10.2106/jbjs.21.00632; URL
Carlini AR, Collins SC, Staguhn ED, Frey KP, O'Toole RV, Archer KR, Obremskey WT, Agel J, Kleweno CP, Morshed S, Weaver MJ, Higgins TF, Bosse MJ, Levy JF, Wu AW, Castillo RC; METRC: Streamlining Trauma Research Evaluation With Advanced Measurement (STREAM) Study: Implementation of the PROMIS Toolbox Within an Orthopaedic Trauma Clinical Trials Consortium; JOT; 2022; URL
Leroux A, Frey KP, Crainiceanu CM, Obremskey WT, Stinner DJ, Bosse MJ, Karunakar MA, O'Toole RV, Carroll EA, Hak DJ, Hayda R, Alkhoury D, Schmidt AH; METRC: Defining Incidence of Acute Compartment Syndrome in the Research Setting: A Proposed Method From the PACS Study; JOT; 2022; URL
Castillo RC, Carlini AR, Chaffee T, Bosse MJ, O'Toole RV, Kleweno CP, McKinley TO, Agel J, Higgins TF, Morshed S, Staguhn ED, Aaron RV, Reider L, Wu AW, MacKenzie EJ; METRC: Long-Term Consequences of Major Extremity Trauma: A Pilot Study.; JOT; 2022; URL
McKinley TO, Gaski GE, Billiar TR, Vodovotz Y, Brown KM, Elster EA, Constantine GM, Schobel SA, Robertson HT, Meagher AD, Firoozabadi R, Gary JL, O'Toole RV, Aneja A, Trochez KM, Kempton LB, Steenburg SD, Collins SC, Frey KP, Castillo RC; METRC: Patient-Specific Precision Injury Signatures to Optimize Orthopaedic Interventions in Multiply Injured Patients (PRECISE STUDY); JOT; 2022; URL
Stinner DJ, Rivera JC, Smith CS, Weiss DB, Hymes RA, Matuszewski PE, Gary JL, Morshed S, Schmidt AH, Wilken JM, Archer KR, Bailey L, Kleihege J, McLaughlin KH, Thompson RE, Chung S, Remenapp C, MacKenzie EJ, Reider L; METRC: Early Advanced Weight-Bearing After Periarticular Fractures: A Randomized Trial Comparing Antigravity Treadmill Therapy Versus Standard of Care; JOT; 2022; URL
Archer KR, Davidson CA, Alkhoury D, Vanston SW, Moore TL, Deluca A, Betz JF, Thompson RE, Obremskey WT, Slobogean GP, Melton DH, Wilken JM, Karunakar MA, Rivera JC, Mir HR, McKinley TO, Frey KP, Castillo RC, Wegener ST; METRC: Cognitive-Behavioral-Based Physical Therapy for Improving Recovery After Traumatic Orthopaedic Lower Extremity Injury (CBPT-Trauma); JOT; 2022; 36; Suppl 1; S1-S7; https://doi.org/10.1097/bot.0000000000002283; URL
McLaughlin KH, Mitchell SL, Archer KR, Master H, Morshed S, Gary JL, Jones CB, MacKenzie EJ, Reider L; METRC: Effect of Severe Distal Tibia, Ankle, and Mid- to Hindfoot Trauma on Meeting Physical Activity Guidelines 18 Months After Injury; Archives of PM&R; 2022; URL

Won NY, Paul A, Garibaldi M, Baumgartner RE, Kaufman KR, Reider L, Wrigley J, Morshed S: Scoping review to evaluate existing measurement parameters and clinical outcomes of transtibial prosthetic alignment and socket fit; Prosthetics and Orthotics International; 2021; URL
Obremskey WT, Tornetta P 3rd, Luly J, Morshed S, O'Toole RV, Hsu JR, Mitchell SL, Mackenzie EJ, Frey KP, Castillo RC, Bosse MJ, Scharfstein DO: Outcomes of Patients with Large versus Small Bone Defects in Open Tibia Fractures Treated with an Intramedullary Nail: A Descriptive Analysis of A Multicenter Retrospective Study; JOT; 2021; URL
Major Extremity Trauma Research Consortium (METRC): Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET); JBJS; 2021; URL
O'Toole RV, Stein DM, Frey KP, O'Hara NN, Scharfstein DO, Slobogean GP, Taylor TJ, Haac BE, Carlini AR, Manson TT, Sudini K, Mullins CD, Wegener ST, Firoozabadi R, Haut ER, Bosse MJ, Seymour RB, Holden MB, Gitajn IL, Goldhaber SZ, Eastman AL, Jurkovich GJ, Vallier HA, Gary JL, Kleweno CP, Cuschieri J, Marvel D, Castillo RC; METRC: PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients; BMJ Open; 2021; URL
Major Extremity Trauma Research Consortium (METRC): Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial; JAMA Surgery; 2021; URL
O'Toole RV, Degani Y, Carlini AR, Castillo RC, O'Hara NN, Joshi M; and METRC: Systemic Absorption and Nephrotoxicity Associated With Topical Vancomycin Powder for Fracture Surgery; JOT; 2021; URL

Reider L, Bai J, Scharfstein DO, Zipunnikov V, for METRC OUTLET Study Investigators: Methods for Step Count Data: Determining "Valid" Days and Quantifying Fragmentation of Walking Bouts; Gait and Posture; 2020; URL
Schmidt AH, Di J, Zipunnikov V, Frey KP, Scharfstein DO, O'Toole RV, Bosse MJ, Obremskey WT, Stinner DJ, Hayda R, Karunakar MA, Hak DJ, Carroll EA, Collins SCJ, MacKenzie EJ; METRC: Perfusion Pressure Lacks Diagnostic Specificity for the Diagnosis of Acute Compartment Syndrome; JOT; 2020; URL
Gitajn IL, Reider L, Scharfstein DO, O'Toole RV, Bosse MJ, Castillo RC, Jevsevar DS, Pollak AN, on behalf of METRC: Variability in discharge disposition across U.S. trauma centers following treatment for high-energy lower extremity injuries; JOT; 2020; URL

Wegener ST, Vallier HA, Huang Y, Gary J, Pollak A, Bosse M, Archer K, Newcome AB, Jones CB, Sietsema DL, Carroll EA, Castillo RC, Collins SC, Frey KP, Scharfstein DO, MacKenzie EJ, and METRC: Early Effects of the Trauma Collaborative Care Intervention Results from a Prospective Multicenter Cluster Clinical Trial; JOT; 2019; URL
O'Hara N, Degani Y, Marvel D, Wells D, Mullins CD, Wegener S, Frey K, Joseph T, Hurst J, Castillo R, O'Toole R on behalf of PREVENT CLOT Stakeholder Committee: Which Orthopaedic Trauma Patients are Likely to Refuse to Participate in a Clinical Trial? A Latent Class Analysis; BMJ Open; 2019; URL
METRC: A Randomized Controlled Trial Comparing rhBMP-2/Absorbable Collagen Sponge Versus Autograft for the Treatment of Tibia Fractures With Critical Size Defects; JOT; 2019; URL
Mitchell SL, Obremskey WT, Luly J, Bosse MJ, Frey KP, Hsu JR, MacKenzie EJ, Morshed S, O'Toole RV, Scharfstein DO, Tornetta P 3rd; METRC: Inter-Rater Reliability of The Modified Radiographic Union Score for Diaphyseal Tibial (mRUST) Fractures with Bone Defects.; JOT; 2019; URL
Castillo RC, Huang Y, Scharfstein D, Frey K, Bosse MJ, Pollak AN, Vallier HA, Archer KR, Hymes RA, Newcomb AB, MacKenzie EJ, Wegener S, METRC: Association Between 6-Week Postdischarge Risk Classification and 12-Month Outcomes After Orthopedic Trauma.; JAMA Surgery; 2019; URL

Potter BK, Sheu RG, Stinner D, Fergason J, Hsu JR, Kuhn K, Owens JG, Rivera J, Shawen SB, Wilken JM, DeSanto J, Huang Y, Scharfstein DO, MacKenzie EJ, the METRC PRIORITI-MTF Team: Multisite Evaluation of a Custom Energy-Storing Carbon Fiber Orthosis for Patients with Residual Disability After Lower-Limb Trauma; JBJS; 2018; URL
Schmidt AH, Bosse MJ, Obremskey WT, O'Toole RV, Carroll EA, Stinner DJ, Hak DJ, Karunakar M, Hayda R, Frey KP, Di J, Zipunnikov V, MacKenzie E; Major Extremity Trauma Research Consortium (METRC): Continuous Near-Infrared Spectroscopy Demonstrates Limitations in Monitoring the Development of Acute Compartment Syndrome in Patients with Leg Injuries.; JBJS; 2018; URL

Wegener ST, Carroll EA, Gary JL, McKinley TO, O_Toole RV, Sietsema DL, Castillo RC, Frey KP, Scharfstein DO, Huang Y, Collins SCJ, MacKenzie EJ and METRC: Trauma Collaborative Care Intervention: Effect on Surgeon Confidence in Managing Psychosocial Complications After Orthopaedic Trauma; JOT; 2017; URL
Wegener ST, Pollak AN, Frey KP, Hymes RA, Archer KR, Jones CB, Seymour RB, O'Toole RV, Castillo RC, Huang Y, Scharfstein DO, MacKenzie EJ and METRC: The Trauma Collaborative Care Study (TCCS); JOT; 2017; URL
Castillo RC, Raja SN, Frey KP, Vallier HA, Tornetta P 3rd, Jaeblon T, Goff BJ, Gottshalk A, Scharfstein DO, O'Toole RV and METRC: Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study); JOT; 2017; URL
Bosse MJ, Morshed S, Reider L, Ertl W, Toledano J, Firoozabadi R, Seymour RB, Carroll E, Scharfstein DO, Steverson B, MacKenzie EJ and METRC: Transtibial Amputation Outcomes Study (TAOS): Comparing Transtibial Amputation with and without a Tibiofibular Synostosis (Ertl) Procedure; JOT; 2017; URL
Hsu JR, Owens JG, DeSanto J, Fergason JR, Kuhn KM, Potter BK, Stinner DJ, Sheu RG, Waggoner SL, Wilken JM, Huang Y, Scharfstein DO, MacKenzie EJ and METRC: Patient Response to an Integrated Orthotic and Rehabilitation Initiative for Traumatic Injuries: The PRIORITI-MTF Study.; JOT; 2017; URL
Bosse MJ, Teague D, Reider L, Gary JL, Morshed S, Seymour RB, Toledano J, Cannads LK, Steverson B, Scharfstein Do, Luly J, MacKenzie EJ and METRC: Outcomes After Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage versus Transtibial Amputation (OUTLET); JOT; 2017; URL
Schmidt AH, Bosse MJ, Frey KP, O'Toole RV, Stinner DJ, Scharfstein DO, Zipunnikov V, MacKenzie EJ, and METRC: Predicting Acute Compartment Syndrome (PACS): The Role of Continuous Monitoring; JOT; 2017; URL
Obremskey WT, Schmidt AH, O'Toole RV, DeSanto J, Morshed S, Tornetta P 3rd, Murray CK, Jones CB, Scharfstein DO, Taylor TJ, Carlini AR, Castillo RC and METRC: A Prospective Randomized Trial to Assess Oral versus Intravenous Antibiotics for the Treatment of Postoperative Wound Infection After Extremity Fractures (POvIV Study); JOT; 2017; URL
O'Toole RV, Joshi M, Carlini AR, Sikorski RA, Dagal A, Murray CK, Weaver MJ, Paryavi E, Stall AC, Scharfstein DO, Agel J, Zadnik M, Bosse MJ, Castillo RC, and METRC: Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High-Energy Fracture Surgery (OXYGEN Study); JOT; 2017; URL
O'Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Scharfstein DO, Gary GL, Bosse MJ, Castillo RC and METRC: Local Antibiotic Therapy to Reduce Infection after Operative Treatment of Fractures at High Risk of Infection: A Multi-center Randomized Controlled Trial (VANCO Study); JOT; 2017; URL
O'Toole RV, Gary JL, Reider L, Bosse MJ, Gordon WT, Hutson J, Quinnan SM, Castillo RC, Scharfstein DO, MacKenzie EJ and METRC: A Prospective Randomized Trial to Assess Fixation Strategies for Severe Open Tibia Fractures: Modern Ring External Fixators versus Internal Fixation (FIXIT Study); JOT; 2017; URL
Bosse MJ, Murray CK, Carlinia AR, Firoozabadi R, Manson T, Scharfstein DO, Wenke JC, Zadnik M, Castillo RC, and METRC: Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage: Correlation with Subsequent Postclosure Deep Wound Infection (Bioburden Study); JOT; 2017; URL
Stinner DJ, Wenke JC, Ficke JR, Gordon W, Toledano J, Carlini AR, Scharfstein DO, MacKenzie EJ, Bosse MJ, Hsu J and METRC: Military and Civilian Collaboration: The Power of Numbers; Military Medicine; 2017; URL

Major Extremity Trauma Research Consortium (METRC): Building a Clinical Research Network in Trauma Orthopaedics: The Major Extremity Trauma Research Consortium (METRC); JOT; 2016; URL
Manson TT, Reider L, O_Toole RV, Scharfstein DO, Tornetta P 3rd, Gary JL; Major Extremity Trauma Research Consortium (METRC): Variation in Treatment of Displaced Geriatric Acetabular Fractures Among 15 Level-I Trauma Centers; JOT; 2016; URL

Castillo RC, Mackenzie EJ, Bosse MJ, METRC Investigators: Measurement of functional outcomes in the Major Extremity Trauma Research Consortium (METRC); JAAOS; 2014; URL

Posters and Presentations


Risk factors for adverse mental health outcomes in FIXIT

Concordance between Traditional Culture and Next Generation Sequencing
AlterG Main Results
The impact of the Single IRB on the optimal number of sites in multicenter trials in orthopaedic trauma
Variability in Treatment of Upper Extremity Peripheral Nerve Injuries Across 17 US Trauma Centers
A Multifactorial Crosswalk Between the SMFA and a Five Item PROMIS Item Bank Set.
Does Objective Data Change the Diagnosis of Acute Compartment Syndrome (ACS) in Patients with Tibia Fractures?
Next-generation Sequencing Results Suggest that a Change in Antibiotic Prophylaxis in Severe Open Tibia Fractures is Warranted
The OTA-Open Fracture Classification (OTA-OFC) Predicts Flap-Related Complications in Severe Open Tibial Fractures?
Increased Operative Time Does Not Increase Deep Infection Rates In Closed Bicondylar Tibial Plateaus Treated With Dual Plating
Deep Surgical Site Infection after Fracture has a Profound Effect on Functional Outcome
Applied Cognition Following Orthopaedic Trauma
Do patients with Orthopaedic Trauma Experience a lower Perceived Ability to Participate in Social Roles and Activities and is there a relationship between their perceived ability and physical reported outcomes?
Does Size Really Matter? Differences in Patients, Injuries and Outcomes Between Large and Small Enrolling Centers in the VANCO & OXYGEN Trials.
Microbial interspecies associations in open fracture and subsequent infection using Next Generation Sequencing
Long-term Functional Outcomes Following Major Lower Limb Trauma Sustained in the Military (METALS 1 )
Physical and Mental Health Effects Diagnosed in Military Service Members following Severe Combat Extremity Trauma (METALS 2)
Do Some Patients Benefit More From Vanco powder? Heterogenous Treatment Effects in the VANCO trial
Patient Satisfaction and Out-of-Pocket Costs Associated with Aspirin and Low-Molecular-Weight Heparin: A Secondary Analysis of the PREVENT CLOT study
Risk-Stratified Thromboprophylaxis Effects of Aspirin Versus Low-Molecular-Weight Heparin in Orthopaedic Trauma Patients
Are Drains Associated With Infection After Operative Fixation Of High-Risk Tibial Plateau And Pilon Fractures?
Risk Factors for Infection in Severe Open Tibial Shaft Fractures
The VANCO Trial Findings Are Generalizable to a North American Trauma Registry
Impact of Surgeon Experience on Major Complications after Ring Fixator Treatment of Severe Open Tibia Fractures
Time-dependent domains of the OTA open fracture classification predict decision to amputate in severe ankle and hindfoot injuries
SAVIT, a Novel Risk Score Based on the OTA Open Fracture Classification, Predicts Limb Salvage after Severe Open Tibia Fractures
A Randomized Trial Comparing Anti-Gravity Treadmill Therapy versus Standard of Care: It's Safe and Patients Like It

Obremskey WT, O'Toole RV, Morshed S, Tornetta P 3rd, Murray CK, Jones CB, Scharfstein DO, Taylor TJ, Carlini AR, DeSanto JM, Castillo RC and METRC. A prospective randomized trial to assess oral (PO) versus intravenous (IV) antibiotics for the treatment of post-op wound infection after extremity fractures (POvIV): A randomized controlled trial. [Abstract, podium presentation] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.
Firoozabadi R, O'Hara NN, Joshi M, Murray CM, Reid JS, Gaski G, Carlini AR, Huang Y, Scharfstein DO, O'Toole RV, Castillo RC, METRC VANCO Study. Do superficial surgical site infections lead to deep surgical site infections after fracture surgery: A secondary analysis of the VANCO trial. [Abstract, poster] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.
Gary JL, Slobogean G, Kleweno CP, Tornetta P, Bosse MJ, Luly J, Carlini AR, Scharfstein DO, Sagi HC, Castillo RC and METRC. A Multicenter Retrospective Review of Pre-Hospital and Emergent Management of Volume Expanding Pelvic Ring Disruption: An Opportunity for Improvement?. [Podium presentation] Submitted to SOMOS/OTA/AOSSM/ASSH Extremity War Injuries XV. 2020.
O'Toole RV, Joshi M, Carlini AR, Huang Y, Murray CM, Bosse MJ, Scharfstein DO, Dagal A, Gary JL, Karunakar M, Weaver MJ, Obremskey WT, McKinley T, Altman G, Sen M, D'Alleyrand JC, Degani Y, Collins SC, Agel J, Taylor TJ, Sikorski R, Stall A, Paryavi E, Holmes A, Zadnik M, Castillo RC, METRC OXYGEN Study. Supplemental perioperative oxygen to reduce surgical site infection after high-energy fracture surgery (OXYGEN study). [Abstract, podium presentation] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.
O'Hara NN, Castillo RC, Carlini AR, Huang Y, Bosse MJ, Obremskey WT, Gary JL, Joshi M, O'Toole RV, METRC VANCO Study. Predicting deep surgical site infections in high-risk tibial plateau and pilon fracture: A secondary analysis of the VANCO trial. [Abstract, poster] Submitted to the 35th Annual Meeting of the Orthopaedic Trauma Association. 2020.

O'Toole RV, Joshi M, Carlini AR, Gary JL, Obremskey WT, Murray C, Gaski G, Reid JS, Degani Y, Taylor TJ, Collins SC, Huang Y, Scharfstein DO, Castillo RC, METRC VANCO Study. Does topical vancomycin powder use in fracture surgery change bacteriology and antibiotic susceptibilities? An analysis of the VANCO trial. [Abstract, podium presentation] Submitted to the 34th Annual Meeting of the Orthopaedic Trauma Association. 2019. *Selected as Highlight Paper.
Murray CK, Yun HC, Joshi M, Carlini AR, Castillo RC, Bosse MJ and METRC Bioburden The efficacy of antibiotic strategies employed at the time of definitive wound closure/coverage for severe lower extremity injuries. [Abstract, podium presentation] Submitted to the 34th Annual Meeting of the Orthopaedic Trauma Association. 2019.

Castillo RC, Carlini AR, Frey KP, O'Toole RV, Archer KR, Obremskey WT, Agel J, Kleweno CP, Morshed SA, Weaver MJ, Higgins TF, Bosse MJ, Collins SC, Wegener ST, Wu AW, Chan KS and METRC. PROMIS PF and SMFA crosswalk: Accuracy varies by domain. [Abstract, poster] Submitted to the Military Health System Research Symposium (MHSRS). 2018.: PDF
Carlini AR, Frey KP, Kirk R, Collins SC, O'Toole RV, Archer KR, Obremskey WT, Agel J, Kleweno CP, Morshed SA, Weaver MJ, Higgins TF, Bosse MJ, Chan KS, Wu AW, Castillo RC and METRC. Implementation of the PROMIS toolbox within an orthopaedic trauma clinical trials consortium. [Abstract, poster] Submitted to the Military Health System Research Symposium (MHSRS). 2018.: PDF
O'Toole RV, Joshi M, Carlini AR, Gary JL, Obremskey WT, Murray CK, Gaski G, Reid JS, Degani Y, Taylor TJ, Collins SC, Huang Y, University of Maryland at Baltimore School Medicine; METRC; Castillo RC. A multicenter randomized trial evaluating intrawound vancomycin powder for reducing surgical site infection after fracture surgery. [Abstract, podium presentation] Submitted to the 33nd Annual Meeting of the Orthopaedic Trauma Association. 2018.
O'Toole RV, Degani Y, Carlini AR, Castillo RC, Joshi M, METRC. Systemic absorption and nephrotoxicity associated with topical vancomycin powder for fracture surgery. [Abstract, podium presentation] Submitted to the 33nd Annual Meeting of the Orthopaedic Trauma Association. 2018.

Castillo RC. The STREAM Study: Streamlining Trauma Research Evaluation with Advanced Measurement. Submitted to the ACRM 94th Annual Conference [podium presentation]. 2017.

Castillo RC, Bosse MJ, Morshed SA, Higgins TF, Archer KR, Agel J, Wu AW, O'Toole RV, Carlini AR, Frey KP, Kirk R, Wegener ST and METRC. Sleep Disturbance Following Orthopaedic Trauma - Does it Predict Future Physical Functioning?. [Abstract, poster] Submitted to the 31st Annual Meeting of the Orthopaedic Trauma Association. 2016.: PDF
Firoozabadi R, Castillo RC, O'Toole RV, Carlini AR, Bosse MJ and METRC. Clinically important subgroups within a large cohort of Gustilo Type IIIB open tibia fractures: An analysis of surgical re-hospitalizations. [Abstract] Submitted to the Military Health System Research Symposium. 2016.

Bosse MJ and the METRC Investigators. Correlation between Routine Microbiology Results at Definitive Closure and Wound Infection in Type III Tibia Fractures: Results from a Multi-Center, Prospective Cohort Study. [Abstract] Submitted to the 30th Annual Meeting of the Orthopaedic Trauma Association. 2015.: PDF
Bosse MJ and the METRC Investigators. How scary is this? Characterizing Antibiotic Use for Type III Tibia Fractures. [Abstract] Submitted to the 30th Annual Meeting of the Orthopaedic Trauma Association. 2015.: PDF
Stinner DJ, Wenke JC, Ficke JR, Gordon W, Toledano J, Carlini AR, Andersen R, Hsu JR and the METRC Investigators. Military and Civilian Collaboration: The Power of Numbers. [Abstract] Submitted to the Military Health System Research Symposium. 2015.
Ballreich J, deLissovoy G, Allen L, Reider L, Frey K, Carlini A, Castillo R, MacKenzie E. Projecting Enrollment Across Multiple Studies in a Clinical Trials Consortium: A Forecasting Tool. [Abstract] Submitted to the 51st Annual Meeting of the Drug Information Association. 2015.

METRC Investigators. Identifying Enrollment Challenges and Discovering Research Opportunities in an Orthopaedic Trauma Consortium: The Value of a "Start-up" Registry. [Scientific Poster #119] Submitted to the 28th Annual Meeting of the Orthopaedic Trauma Association. 2012.: PDF
METRC Investigators. "Apples-to-Apples" - Moving to the New OTA Fracture Severity Classification in Extremity Trauma Research. [Scientific Poster #121] Submitted to the 28th Annual Meeting of the Orthopaedic Trauma Association. 2012.: PDF

Disparate Care Utilization for Rehabilitation of Severe Combat Sustained Extremity Trauma Drive by Limb Reconstruction (METALS 4)
Physical and Mental Health Effects Diagnosed in Military Service Members following Severe Combat Extremity Trauma (METALS 3)
Modern External Ring Fixation Versus Internal Fixation in Severe Open Tibia Fractures Treated by Surgeons with Prior Ring Experience

Clinical Practice Guidelines & Appropriate Use Criteria

AUC Summary Paper: Early Screening for Psychosocial Risk Factors: URL
AUC Case Study Paper: Prevention and Treatment of Surgical Site Infection: URL
AUC Summary Paper: Prevention and Treatment of Surgical Site Infection: URL
AUC Summary Paper: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
AUC: Prevention and Treatment of Surgical Site Infection: URL
CPG: Prevention and Treatment of Surgical Site Infection: URL
AUC Case Study Paper: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
CPG Case Study Paper: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
CPG Summary Paper: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
AUC: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
CPG: Use of Multimodal Perioperative Pharmacologic Pain Management: URL
AUC Case Study Paper: Early Screening for Psychosocial Risk Factors: URL
Appropriate Use Criteria (AUC) for the Limb Salvage or Early Amputation: URL
CPG Summary Paper: Early Screening for Psychosocial Risk Factors: URL
CPG Summary Paper: Limb Salvage or Early Limb Amputation: URL
AUC: Early Screening for Psychosocial Risk Factors: URL
AUC: Diagnosis and Treatment of Acute Compartment Syndrome: URL
AAOS Prevention of Surgical Site Infection After Extremity Trauma Guideline Summary: URL
2021 AAOS Clinical Practice Guideline Summary: Management of Acute Compartment Syndrome: URL
2021 AAOS Clinical Practice Guideline Case Studies: Management of Acute Compartment Syndrome: URL
2021 AAOS Appropriate Use Criteria Summary: Diagnosis and Management of Acute Compartment Syndrome: URL
2018 AAOS/METRC CPG on Management of Acute Compartment Syndrome: URL
2019 AAOS/METRC CPG on Limb Salvage or Early Amputation: URL
2019 AAOS/METRC CPG on the Evaluation of Psychosocial Factors Influencing Recovery from Adult Orthopaedic Trauma: URL